Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Jr Donohue, D. L. Clemens, A. Galli, D. Crabb, N. Nieto, J. Kato, S. S. Barve

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Terrence M. Donohue, Jr, and Dahn L. Clemens. The presentations were (1) Characterization of single and double recombinant hepatoma cells that express ethanol-metabolizing enzymes, by Terrence M. Donohue, Jr; (2) Inhibition of cell growth by ethanol metabolism, by Dahn L. Clemens; (3) Use of transfected HeLa cells to study the genesis of alcoholic fatty liver, by Andrea Galli and David Crabb; (4) CYP2E1-mediated oxidative stress induces COL1A2 mRNA in hepatic stellate cells and in a coculture system of HepG2 and stellate cells, by Natalia Nieto; (5) Transforming growth factor-α secreted from ethanol-exposed hepatocytes contributes to development of alcoholic hepatic fibrosis, by Junji Kato; and (6) Effect of ethanol on Fas-dependent caspase-3 activation and apoptosis in CD4+ T cells, by Shirish S. Barve.

Original languageEnglish (US)
Pages (from-to)87S-93S
JournalAlcoholism: Clinical and Experimental Research
Issue number5 SUPPL.
StatePublished - 2001
Externally publishedYes


  • Alcoholic Fatty Liver
  • Apoptosis
  • CYP2E1
  • HeLa Cells
  • Hepatoma Cells
  • Transforming Growth Factor-α

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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