Use of disodium pamidronate in children with hypercalcemia awaiting liver transplantation

Thomas M. Attard; Anil Dhawan; Stuart S. Kaufman; Dean S. Collier; Alan N. Langnas

Use of disodium pamidronate in children with hypercalcemia awaiting liver transplantation

Thomas M. Attard, Anil Dhawan, Stuart S. Kaufman, Dean S. Collier, Alan N. Langnas

Research output: Contribution to journal › Article › peer-review

Abstract

We report four children with advanced liver disease awaiting liver transplantation who developed moderately severe hypercalcemia (range: 1.65-2.40 mmol/L) while receiving total parenteral nutrition. Hypercalcemia had been unresponsive to cessation of calcium intake and therapy with loop diuretics and calcitonin. One or two intravenous doses of disodium pamidronate (35-50 mg/m²) resulted in normalization of plasma calcium concentration within 2-4 d in all four children. Pamidronate may be useful for children with hypercalcemia associated with liver disease.

Original language	English (US)
Pages (from-to)	157-159
Number of pages	3
Journal	Pediatric Transplantation
Volume	2
Issue number	2
State	Published - 1998

Keywords

Bisphospnonate pamidronate
Child
Hypercalcemia
Liver transplantation
Short bowel syndrome
Total parenteral nutrition

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

Cite this

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abstract = "We report four children with advanced liver disease awaiting liver transplantation who developed moderately severe hypercalcemia (range: 1.65-2.40 mmol/L) while receiving total parenteral nutrition. Hypercalcemia had been unresponsive to cessation of calcium intake and therapy with loop diuretics and calcitonin. One or two intravenous doses of disodium pamidronate (35-50 mg/m2) resulted in normalization of plasma calcium concentration within 2-4 d in all four children. Pamidronate may be useful for children with hypercalcemia associated with liver disease.",

keywords = "Bisphospnonate pamidronate, Child, Hypercalcemia, Liver transplantation, Short bowel syndrome, Total parenteral nutrition",

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AU - Attard, Thomas M.

AU - Dhawan, Anil

AU - Kaufman, Stuart S.

AU - Collier, Dean S.

AU - Langnas, Alan N.

PY - 1998

Y1 - 1998

N2 - We report four children with advanced liver disease awaiting liver transplantation who developed moderately severe hypercalcemia (range: 1.65-2.40 mmol/L) while receiving total parenteral nutrition. Hypercalcemia had been unresponsive to cessation of calcium intake and therapy with loop diuretics and calcitonin. One or two intravenous doses of disodium pamidronate (35-50 mg/m2) resulted in normalization of plasma calcium concentration within 2-4 d in all four children. Pamidronate may be useful for children with hypercalcemia associated with liver disease.

AB - We report four children with advanced liver disease awaiting liver transplantation who developed moderately severe hypercalcemia (range: 1.65-2.40 mmol/L) while receiving total parenteral nutrition. Hypercalcemia had been unresponsive to cessation of calcium intake and therapy with loop diuretics and calcitonin. One or two intravenous doses of disodium pamidronate (35-50 mg/m2) resulted in normalization of plasma calcium concentration within 2-4 d in all four children. Pamidronate may be useful for children with hypercalcemia associated with liver disease.

KW - Bisphospnonate pamidronate

KW - Child

KW - Hypercalcemia

KW - Liver transplantation

KW - Short bowel syndrome

KW - Total parenteral nutrition

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Use of disodium pamidronate in children with hypercalcemia awaiting liver transplantation

Abstract

Keywords

ASJC Scopus subject areas

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