Use of letermovir for salvage therapy for resistant cytomegalovirus in a pediatric hematopoietic stem cell transplant recipient

Jacob T. Kilgore, Bradford Becken, Matthew G. Varga, Suhag Parikh, Vinod Prasad, Debra Lugo, Yeh Chung Chang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed recurrent DNAemia with laboratory-confirmed ganciclovir, foscarnet, and letermovir resistance.

Original languageEnglish (US)
Pages (from-to)486-489
Number of pages4
JournalJournal of the Pediatric Infectious Diseases Society
Volume9
Issue number4
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Antiviral resistance
  • Cytomegalovirus (CMV)
  • Hematopoietic stem cell transplant
  • Letermovir

ASJC Scopus subject areas

  • Medicine(all)

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