Abstract
D-Cycloserine (DCS) is only used with multidrug-resistant strains of tuberculosis because of serious side effects. DCS is known to inhibit cell wall biosynthesis, but the in vivo lethal target is still unknown. We have applied NMR-based metabolomics combined with principal component analysis to monitor the in vivo effect of DCS on Mycobacterium smegmatis. Our analysis suggests DCS functions by inhibiting multiple protein targets.
Original language | English (US) |
---|---|
Pages (from-to) | 4608-4614 |
Number of pages | 7 |
Journal | Journal of proteome research |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2007 |
Keywords
- D-alanine racemase
- D-cycloserine
- Metabolomics
- Mycobacterium smegmatis
- NMR
- Principal component analysis
- Tuberculosis
ASJC Scopus subject areas
- Biochemistry
- Chemistry(all)