Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Adam McQuistan, Anita J. Zaitouna, Elena Echeverria, Rebecca Y. Lai

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.

Original languageEnglish (US)
Pages (from-to)4690-4692
Number of pages3
JournalChemical Communications
Volume50
Issue number36
DOIs
StatePublished - Apr 8 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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