Abstract
We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4690-4692 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 36 |
| DOIs | |
| State | Published - Apr 8 2014 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
McQuistan, A., Zaitouna, A. J., Echeverria, E., & Lai, R. Y. (2014). Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors. Chemical Communications, 50(36), 4690-4692. https://doi.org/10.1039/c4cc01290a