Usefulness of Charlson Comorbidity Index to Predict Early Mortality and Overall Survival in Older Patients With Acute Myeloid Leukemia

Prajwal Dhakal; Valerie Shostrom; Zaid S. Al-Kadhimi; Lori J. Maness; Krishna Gundabolu; Vijaya Raj Bhatt

doi:10.1016/j.clml.2020.07.002

Usefulness of Charlson Comorbidity Index to Predict Early Mortality and Overall Survival in Older Patients With Acute Myeloid Leukemia

Prajwal Dhakal, Valerie Shostrom, Zaid S. Al-Kadhimi, Lori J. Maness, Krishna Gundabolu, Vijaya Raj Bhatt

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We hypothesized that higher Charlson comorbidity index (CCI) predicts worse 1-month mortality and overall survival (OS) in patients ≥60 years with acute myeloid leukemia (AML). In our National Cancer Database study, patients with CCI 0 were more likely to receive chemotherapy and undergo upfront hematopoietic cell transplantation. One-month mortality and OS were significantly worse with CCI 1 or ≥2, compared with CCI 0.

Original language	English (US)
Pages (from-to)	804-812.e8
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.clml.2020.07.002
State	Published - Dec 2020

Keywords

Acute leukemia
Chemotherapy
Geriatrics
Older adults
Survival

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2020.07.002

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title = "Usefulness of Charlson Comorbidity Index to Predict Early Mortality and Overall Survival in Older Patients With Acute Myeloid Leukemia",

abstract = "We hypothesized that higher Charlson comorbidity index (CCI) predicts worse 1-month mortality and overall survival (OS) in patients ≥60 years with acute myeloid leukemia (AML). In our National Cancer Database study, patients with CCI 0 were more likely to receive chemotherapy and undergo upfront hematopoietic cell transplantation. One-month mortality and OS were significantly worse with CCI 1 or ≥2, compared with CCI 0.",

keywords = "Acute leukemia, Chemotherapy, Geriatrics, Older adults, Survival",

author = "Prajwal Dhakal and Valerie Shostrom and Al-Kadhimi, {Zaid S.} and Maness, {Lori J.} and Krishna Gundabolu and Bhatt, {Vijaya Raj}",

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AU - Dhakal, Prajwal

AU - Shostrom, Valerie

AU - Al-Kadhimi, Zaid S.

AU - Maness, Lori J.

AU - Gundabolu, Krishna

AU - Bhatt, Vijaya Raj

PY - 2020/12

Y1 - 2020/12

N2 - We hypothesized that higher Charlson comorbidity index (CCI) predicts worse 1-month mortality and overall survival (OS) in patients ≥60 years with acute myeloid leukemia (AML). In our National Cancer Database study, patients with CCI 0 were more likely to receive chemotherapy and undergo upfront hematopoietic cell transplantation. One-month mortality and OS were significantly worse with CCI 1 or ≥2, compared with CCI 0.

AB - We hypothesized that higher Charlson comorbidity index (CCI) predicts worse 1-month mortality and overall survival (OS) in patients ≥60 years with acute myeloid leukemia (AML). In our National Cancer Database study, patients with CCI 0 were more likely to receive chemotherapy and undergo upfront hematopoietic cell transplantation. One-month mortality and OS were significantly worse with CCI 1 or ≥2, compared with CCI 0.

KW - Acute leukemia

KW - Chemotherapy

KW - Geriatrics

KW - Older adults

KW - Survival

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ER -

Usefulness of Charlson Comorbidity Index to Predict Early Mortality and Overall Survival in Older Patients With Acute Myeloid Leukemia

Abstract

Keywords

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