Using databases and computational techniques to infer the function of novel proteins

Viswanathan Ramanathan, Kelly A. Mercier, Robert Powers, Peter Z. Revesz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Human Genome Project and similar efforts have resulted in the identification of an abundance of novel proteins. There is a need to expedite the process of assigning function to novel proteins. Nuclear magnetic resonance (NMR) spectroscopy can be used to infer a general biological function for a protein of unknown function by identifying compounds that preferentially bind the protein and comparing these results against proteins with defined structure and function. The Functional NMR screen generates hundreds of data sets and a manual analysis of these data sets is laborious and time-consuming. It is hypothesized that several sub-tasks of the Functional NMR can be automated successfully using an integrated database and data analysis system. Our database system integrates NMR data collection, processing, analysis, and data archiving into a unified user interface. An NMR spectra comparison algorithm is designed and implemented to compare NMR data in the presence and absence of a protein to ascertain if any compound-protein binding occurred.

Original languageEnglish (US)
Title of host publication2005 IEEE International Conference on Electro Information Technology
StatePublished - 2005
Event2005 IEEE International Conference on Electro Information Technology - Lincoln, NE, United States
Duration: May 22 2005May 25 2005

Publication series

Name2005 IEEE International Conference on Electro Information Technology
Volume2005

Conference

Conference2005 IEEE International Conference on Electro Information Technology
CountryUnited States
CityLincoln, NE
Period5/22/055/25/05

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Ramanathan, V., Mercier, K. A., Powers, R., & Revesz, P. Z. (2005). Using databases and computational techniques to infer the function of novel proteins. In 2005 IEEE International Conference on Electro Information Technology [1626981] (2005 IEEE International Conference on Electro Information Technology; Vol. 2005).