Using proteomics to uncover extracellular matrix interactions during cardiac remodeling

Nicolle L. Patterson, Rugmani Padmanabhan Iyer, Lisandra E. de Castro Brás, Yaojun Li, Thomas G. Andrews, Gregory J. Aune, Richard A. Lange, Merry L. Lindsey

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The left ventricle (LV) responds to a myocardial infarction with an orchestrated sequence of events that result in fundamental changes to both the structure and function of the myocardium. This collection of responses is termed as LV remodeling. Myocardial ischemia resulting in necrosis is the initiating event that culminates in the formation of an extracellular matrix (ECM) rich infarct scar that replaces necrotic myocytes. While the cardiomyocyte is the major cell type that responds to ischemia, infiltrating leukocytes and cardiac fibroblasts coordinate the subsequent wound healing response. The matrix metalloproteinase family of enzymes regulates the inflammatory and ECM responses that modulate scar formation. Matridomics is the proteomic evaluation focused on ECM, while degradomics is the proteomic evaluation of proteases as well as their inhibitors and substrates. This review will summarize the use of proteomics to better understand matrix metalloproteinase roles in post myocardial infarction LV remodeling.

Original languageEnglish (US)
Pages (from-to)516-527
Number of pages12
JournalProteomics - Clinical Applications
Volume7
Issue number7-8
DOIs
StatePublished - Aug 2013

Keywords

  • Degradomics
  • Matridomics
  • Matrix metalloproteinases
  • Myocardial infarction

ASJC Scopus subject areas

  • Clinical Biochemistry

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  • Cite this

    Patterson, N. L., Iyer, R. P., de Castro Brás, L. E., Li, Y., Andrews, T. G., Aune, G. J., Lange, R. A., & Lindsey, M. L. (2013). Using proteomics to uncover extracellular matrix interactions during cardiac remodeling. Proteomics - Clinical Applications, 7(7-8), 516-527. https://doi.org/10.1002/prca.201200100