Using salivary glands as a tissue target for gene therapeutics

A. T.M. Shamsul Hoque, Seiichi Yamano, Lorena Baccaglini, Bruce J. Baum

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo animal models. In that context we discuss problems (general and salivary tissue-specific) that limit immediate clinical use for this application of gene transfer. Ongoing efforts, however, suggest that salivary glands may be suitable as gene therapeutic target sites for drug delivery in the near future.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalJournal of Drug Targeting
Volume9
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Gene therapeutics
  • Gene transfer
  • Protein deficiency disorders
  • Protein secretion
  • Salivary glands

ASJC Scopus subject areas

  • Pharmaceutical Science

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