Uteroplacental blood flow during pregnancy in chronically catheterized guinea pigs

L. L.H. Peeters, J. W. Sparks, G. Grutters, J. Girard, F. C. Battaglia

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Uterine blood flow and its distribution to uterus, placenta and subplacental structures was measured in 18 pregnant guinea pigs studied under chronic steady-state conditions. Maternal cardiac output averaged 266 ± 14 ml/min. Placental blood flow (PBF) remained less than 4 ml/min until 50 days gestation, after which it increased rapidly, attaining flows of 16 ml/min at term. PBF also increased linearly with placental weight (r = 0.76, P< 0.001); however, the increase in PBF with gestational age is evident even in narrow weight ranges, indicating hyperperfusion of term placentas relative to those earlier in gestation. Fetal weight correlated with measured placental blood flow supplying the corresponding placenta after 50 days gestation (r = 0.72, P < 0.001). Speculation: Placental blood flow appears to be an important independent determinant of spontaneous fetal size. Measurement of uteroplacental blood flow under unstressed conditions accurately describes normal uteroplacental blood flow and may provide more reliable characterizations of the relationships between uteroplacental blood flow, placental size, and fetal growth.

Original languageEnglish (US)
Pages (from-to)716-720
Number of pages5
JournalPediatric Research
Issue number9
StatePublished - Sep 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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