Variable presence of circulating cytokines in patients with sporadic or x-linked lymphoproliferative disease with fatal infectious mononucleosis

Motohiko Okano; Geoffrey M. Thiele; David T. Purtilo

doi:10.3109/08880019309016535

Variable presence of circulating cytokines in patients with sporadic or x-linked lymphoproliferative disease with fatal infectious mononucleosis

Motohiko Okano, Geoffrey M. Thiele, David T. Purtilo

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

Abstract

Infectious mononucleosis (IM), caused by primary infection of Epstein-Barr virus (EBV), is a self-limiting benign lymphoproliferative disease.¹ Rare cases, however, develop severe or fatal IM (SIM or FIM) either sporadically or with X-linked lymphoproliferative disease (XLP).^1,2 The pathogenetic mechanism) responsible for SIM or FIM remain unknown mainly owing to the limited number of cases and the difficulties in establishing a precise diagnosis.

Original language	English (US)
Pages (from-to)	97-99
Number of pages	3
Journal	Pediatric Hematology and Oncology
Volume	10
Issue number	1
DOIs	https://doi.org/10.3109/08880019309016535
State	Published - 1993

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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@article{060c89a74246439ab912504280cdf0b8,

title = "Variable presence of circulating cytokines in patients with sporadic or x-linked lymphoproliferative disease with fatal infectious mononucleosis",

abstract = "Infectious mononucleosis (IM), caused by primary infection of Epstein-Barr virus (EBV), is a self-limiting benign lymphoproliferative disease.1 Rare cases, however, develop severe or fatal IM (SIM or FIM) either sporadically or with X-linked lymphoproliferative disease (XLP).1,2 The pathogenetic mechanism) responsible for SIM or FIM remain unknown mainly owing to the limited number of cases and the difficulties in establishing a precise diagnosis.",

author = "Motohiko Okano and Thiele, {Geoffrey M.} and Purtilo, {David T.}",

note = "Funding Information: 'Deceased. This work is dedicated to the memory of David T. Purtilo, M.D., a pioneer in the study of EBV and immunodeficiency diseases. This work was supported in part by PHS CA30196 and CA36727 awarded by the National Cancer Institute, Department of Health and Human Services, and the Lymphoproliferative Research Fund.",

year = "1993",

doi = "10.3109/08880019309016535",

language = "English (US)",

volume = "10",

pages = "97--99",

journal = "Pediatric Hematology and Oncology",

issn = "0888-0018",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Variable presence of circulating cytokines in patients with sporadic or x-linked lymphoproliferative disease with fatal infectious mononucleosis

AU - Okano, Motohiko

AU - Thiele, Geoffrey M.

AU - Purtilo, David T.

N1 - Funding Information: 'Deceased. This work is dedicated to the memory of David T. Purtilo, M.D., a pioneer in the study of EBV and immunodeficiency diseases. This work was supported in part by PHS CA30196 and CA36727 awarded by the National Cancer Institute, Department of Health and Human Services, and the Lymphoproliferative Research Fund.

PY - 1993

Y1 - 1993

N2 - Infectious mononucleosis (IM), caused by primary infection of Epstein-Barr virus (EBV), is a self-limiting benign lymphoproliferative disease.1 Rare cases, however, develop severe or fatal IM (SIM or FIM) either sporadically or with X-linked lymphoproliferative disease (XLP).1,2 The pathogenetic mechanism) responsible for SIM or FIM remain unknown mainly owing to the limited number of cases and the difficulties in establishing a precise diagnosis.

AB - Infectious mononucleosis (IM), caused by primary infection of Epstein-Barr virus (EBV), is a self-limiting benign lymphoproliferative disease.1 Rare cases, however, develop severe or fatal IM (SIM or FIM) either sporadically or with X-linked lymphoproliferative disease (XLP).1,2 The pathogenetic mechanism) responsible for SIM or FIM remain unknown mainly owing to the limited number of cases and the difficulties in establishing a precise diagnosis.

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U2 - 10.3109/08880019309016535

DO - 10.3109/08880019309016535

M3 - Letter

C2 - 8382935

AN - SCOPUS:0027349260

SN - 0888-0018

VL - 10

SP - 97

EP - 99

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

IS - 1

ER -

Variable presence of circulating cytokines in patients with sporadic or x-linked lymphoproliferative disease with fatal infectious mononucleosis

Abstract

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