Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV

Vanessa Rivera-Amill; Richard J. Noel; Suheydi Orsini; Griselle Tirado; José M. García; Shilpa Buch; Anil Kumar

doi:10.1016/j.virol.2006.08.039

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV

Vanessa Rivera-Amill, Richard J. Noel, Suheydi Orsini, Griselle Tirado, José M. García, Shilpa Buch, Anil Kumar

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

Original language	English (US)
Pages (from-to)	373-383
Number of pages	11
Journal	Virology
Volume	358
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2006.08.039
State	Published - Feb 20 2007
Externally published	Yes

Keywords

Envelope evolution
Macaque
Morphine
SHIV
SIV
Variable region

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2006.08.039

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title = "Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV",

abstract = "We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.",

keywords = "Envelope evolution, Macaque, Morphine, SHIV, SIV, Variable region",

author = "Vanessa Rivera-Amill and Noel, {Richard J.} and Suheydi Orsini and Griselle Tirado and Garc{\'i}a, {Jos{\'e} M.} and Shilpa Buch and Anil Kumar",

note = "Funding Information: We thank Dr. Martin Hill, Department of Physiology and Pharmacology, Ponce School of Medicine for insightful discussions. We acknowledge the support of the Molecular Biology Core and the RCMI Publications Office (Grant # 2G12RR003050-21). This work was supported by National Institute on Drug Abuse (DA015013) and National Institute on Alcohol and Alcoholism (AA015045). ",

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AU - Rivera-Amill, Vanessa

AU - Noel, Richard J.

AU - Orsini, Suheydi

AU - Tirado, Griselle

AU - García, José M.

AU - Buch, Shilpa

AU - Kumar, Anil

N1 - Funding Information: We thank Dr. Martin Hill, Department of Physiology and Pharmacology, Ponce School of Medicine for insightful discussions. We acknowledge the support of the Molecular Biology Core and the RCMI Publications Office (Grant # 2G12RR003050-21). This work was supported by National Institute on Drug Abuse (DA015013) and National Institute on Alcohol and Alcoholism (AA015045).

PY - 2007/2/20

Y1 - 2007/2/20

N2 - We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

AB - We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

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KW - SIV

KW - Variable region

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Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV

Abstract

Keywords

ASJC Scopus subject areas

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