Variation in toll-like receptor 4 and susceptibility to group a meningococcal meningitis in Gambian children

Angela Allen, Stephen Obaro, Kalifa Bojang, Agnes A. Awomoyi, Brian M. Greenwood, Hilton Whittle, Giorgio Sirugo, Melanie J. Newport

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Meningitis is an important cause of childhood mortality in sub-Saharan Africa. A case-control study investigating the role of the Toll-like receptor 4 gene in host susceptibility to Group A Neisseria meningitidis meningitis was conducted in 524 Gambian children. There was no association between a functional Toll-like receptor 4 gene polymorphism and meningitis, suggesting that this variant is not a major determinant of disease in this population.

Original languageEnglish (US)
Pages (from-to)1018-1019
Number of pages2
JournalPediatric Infectious Disease Journal
Volume22
Issue number11
DOIs
StatePublished - Nov 2003

Keywords

  • Epidemic
  • Genetic
  • Meningitis
  • Sub-Saharan Africa
  • Susceptibility
  • Toll-like receptor 4

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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