Variations in centromeric heterochromatin among patients with pre‐malignant and malignant oral diseases

Bhavana J. Dave, Amit H. Trivedi, Siddharth G. Adhvaryu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Polymorphism of heterochromatic regions of chromosomes 1, 9 and 16 was studied in 60 oral cancer patients, in 40 patients with oral submucous fibrosis (OSMF) and in 60 normal healthy subjects. The size heteromorphism was significantly greater (p < 0.001) in chromosome 1 of the patients. Localization variants were also significantly more frequent among the patients (p < 0.05 for OSMF and < 0.001 for oral cancer patients). The C‐band heteromorphism patterns remained comparable in OSMF and in oral cancer patients, with chromosome 1 being the most frequently involved. On correlating the tobacco/areca‐nut chewing habit with the presence of C‐band heteromorphism, we observed that C‐band heteromorphism was present in 89% of the habit‐free oral cancer patients and 80% of the OSMF patients with relatively shorter exposure to this habit, i.e. < 5 years. This signifies that genetic factors are important in the causation of oral precancerous and cancerous conditions and that polymorphism of the heterochromatic regions does appear to play a role in these conditions.

Original languageEnglish (US)
Pages (from-to)386-389
Number of pages4
JournalInternational Journal of Cancer
Volume48
Issue number3
DOIs
StatePublished - May 30 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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