Variations in the csgD promoter of Escherichia coli O157:H7 associated with increased virulence in mice and increased invasion of HEp-2 cells

G. A. Uhlich, J. E. Keen, R. O. Elder

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Promoter alterations in the csgD gene of Escherichia coli O157:H7 strains ATCC 43894 and ATCC 43895 are associated with variations in curli expression and the ability to bind Congo red dye. Red variants of each strain were more invasive for cultured HEp-2 cells than were white variants. An ATCC 43895 red variant was more virulent than a white variant in a mouse model. However, there were no differences in Shiga toxin production between red and white variants.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalInfection and immunity
Volume70
Issue number1
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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