Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases

Wenyan Xu, Liling Li, Liangcheng Du, Ninghua Tan

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalActa Biochimica et Biophysica Sinica
Volume43
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • cyclization mechanism
  • cyclopeptides
  • non-ribosomal peptide synthetase
  • ribosomal peptide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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