TY - JOUR
T1 - Vasculitic neuropathy associated with minocycline use
AU - Thaisetthawatkul, Pariwat
AU - Sundell, Robert
AU - Robertson, Carrie E.
AU - Dyck, Peter J.
PY - 2011/6
Y1 - 2011/6
N2 - INTRODUCTION: Minocycline is an antibiotic used for the treatment of acne. It has been associated with several autoimmune syndromes, including drug-induced lupus, autoimmune hepatitis, and vasculitis. METHOD AND RESULTS: We report a case of a 28-year-old previously healthy woman who developed a left sciatic mononeuropathy 2 weeks after starting minocycline for acne. Magnetic resonance imaging studies supported the localization. A biopsy of the left sural nerve revealed acute nerve large arteriole necrotizing vasculitis. Her condition improved after the withdrawal of minocycline and a course of treatment with methylprednisolone. CONCLUSION: This case provides further evidence that minocycline may induce a nonsystemic necrotizing vasculitis.
AB - INTRODUCTION: Minocycline is an antibiotic used for the treatment of acne. It has been associated with several autoimmune syndromes, including drug-induced lupus, autoimmune hepatitis, and vasculitis. METHOD AND RESULTS: We report a case of a 28-year-old previously healthy woman who developed a left sciatic mononeuropathy 2 weeks after starting minocycline for acne. Magnetic resonance imaging studies supported the localization. A biopsy of the left sural nerve revealed acute nerve large arteriole necrotizing vasculitis. Her condition improved after the withdrawal of minocycline and a course of treatment with methylprednisolone. CONCLUSION: This case provides further evidence that minocycline may induce a nonsystemic necrotizing vasculitis.
KW - drug-induced neuropathy
KW - inflammatory neuropathy
KW - minocycline
KW - peripheral neuropathy
KW - vasculitic neuropathy
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U2 - 10.1097/CND.0b013e3181ee155d
DO - 10.1097/CND.0b013e3181ee155d
M3 - Article
C2 - 22361522
AN - SCOPUS:79958830570
SN - 1522-0443
VL - 12
SP - 231
EP - 234
JO - Journal of Clinical Neuromuscular Disease
JF - Journal of Clinical Neuromuscular Disease
IS - 4
ER -