VCL-ALK renal cell carcinoma in children with sickle-cell trait: The eighth sickle-cell nephropathy?

Nathaniel E. Smith, Andrea T. Deyrup, Adrian Mariño-Enriquez, Jonathan A. Fletcher, Julia A. Bridge, Peter B. Illei, George J. Netto, Pedram Argani

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.

Original languageEnglish (US)
Pages (from-to)858-863
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number6
DOIs
StatePublished - 2014

Keywords

  • Anaplastic lymphoma kinase
  • Renal cell carcinoma
  • Vinculin

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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    Smith, N. E., Deyrup, A. T., Mariño-Enriquez, A., Fletcher, J. A., Bridge, J. A., Illei, P. B., Netto, G. J., & Argani, P. (2014). VCL-ALK renal cell carcinoma in children with sickle-cell trait: The eighth sickle-cell nephropathy? American Journal of Surgical Pathology, 38(6), 858-863. https://doi.org/10.1097/PAS.0000000000000179