TY - JOUR
T1 - Ventricular shunt infections
T2 - Immunopathogenesis and clinical management
AU - Gutierrez-Murgas, Yenis
AU - Snowden, Jessica N.
N1 - Funding Information:
The authors thank Tammy Kielian PhD, Gary Beck PhD and the University of Nebraska Medical Center Pediatric Writing Group for their assistance in the review and revision of this manuscript. The authors acknowledge funding from the Fullbright-Cerrejon Scholarship to YGM and the Cheryl Ann Lozier Memorial Research Fund , Edna Ittner Pediatric Research Support Fund , and National Institute of Neurologic Disorders and Stroke ( 1K08NS069812-01 ) to JNS. Additional support is provided by the University of Nebraska Medical Center Departments of Pediatrics and Pathology/Microbiology.
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - Ventricular shunts are the most common neurosurgical procedure performed in the United States. This hydrocephalus treatment is often complicated by infection of the device with biofilm-forming bacteria. In this review, we discuss the pathogenesis of shunt infection, as well as the implications of the biofilm formation on treatment and prevention of these infections. Many questions remain, including the contribution of glia and the impact of inflammation on developmental outcomes following infection. Immune responses within the CNS must be carefully regulated to contain infection while minimizing bystander damage; further study is needed to design optimal treatment strategies for these patients.
AB - Ventricular shunts are the most common neurosurgical procedure performed in the United States. This hydrocephalus treatment is often complicated by infection of the device with biofilm-forming bacteria. In this review, we discuss the pathogenesis of shunt infection, as well as the implications of the biofilm formation on treatment and prevention of these infections. Many questions remain, including the contribution of glia and the impact of inflammation on developmental outcomes following infection. Immune responses within the CNS must be carefully regulated to contain infection while minimizing bystander damage; further study is needed to design optimal treatment strategies for these patients.
KW - Biofilm
KW - Catheter
KW - Central nervous system
KW - Shunt infection
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U2 - 10.1016/j.jneuroim.2014.08.006
DO - 10.1016/j.jneuroim.2014.08.006
M3 - Review article
C2 - 25156073
AN - SCOPUS:84908506007
SN - 0165-5728
VL - 276
SP - 1
EP - 8
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -