Ventromedial prefrontal cortex is critical for helping others who are suffering

Janelle N. Beadle, Sergio Paradiso, Daniel Tranel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Neurological patients with damage to the ventromedial prefrontal cortex (vmPFC) are reported to display reduced empathy toward others in their daily lives in clinical case studies. However, the empathic behavior of patients with damage to the vmPFC has not been measured experimentally in response to an empathy-eliciting event. This is important because characterizing the degree to which patients with damage to the vmPFC have lower empathic behavior will allow for the development of targeted interventions to improve patients' social skills and in turn will help family members to better understand their impairments so they can provide appropriate supports. For the first time, we induced empathy using an ecologically-valid empathy induction in neurological patients with damage to the vmPFC and measured their empathic emotional responses and behavior in real time. Eight neurological patients with focal damage to the vmPFC were compared to demographically-matched brain-damaged and healthy comparison participants. Patients with damage to the vmPFC gave less money in the empathy condition to a person who was suffering (a confederate) than comparison participants. This provides the first direct experimental evidence that the vmPFC is critical for empathic behavior toward individuals who are suffering.

Original languageEnglish (US)
Article number288
JournalFrontiers in Neurology
Issue numberMAY
StatePublished - May 25 2018


  • Empathy
  • Financial decision making
  • Lesion study
  • Prosocial behavior
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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