Vertical transmission of Kaposi's sarcoma-associated herpesvirus

Hamakwa Mantina, Chipepo Kankasa, Winslow Klaskala, Brad Brayfield, James Campbell, Quijiang Du, Ganapati Bhat, Francis Kasolo, Charles Mitchell, Charles Wood

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.

Original languageEnglish (US)
Pages (from-to)749-752
Number of pages4
JournalInternational Journal of Cancer
Volume94
Issue number5
DOIs
StatePublished - Dec 1 2001

Keywords

  • HHV-8
  • KSHV
  • Vertical transmission

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Mantina, H., Kankasa, C., Klaskala, W., Brayfield, B., Campbell, J., Du, Q., Bhat, G., Kasolo, F., Mitchell, C., & Wood, C. (2001). Vertical transmission of Kaposi's sarcoma-associated herpesvirus. International Journal of Cancer, 94(5), 749-752. https://doi.org/10.1002/ijc.1529