Vertical transmission of Kaposi's sarcoma-associated herpesvirus

Hamakwa Mantina; Chipepo Kankasa; Winslow Klaskala; Brad Brayfield; James Campbell; Quijiang Du; Ganapati Bhat; Francis Kasolo; Charles Mitchell; Charles Wood

doi:10.1002/ijc.1529

Vertical transmission of Kaposi's sarcoma-associated herpesvirus

Hamakwa Mantina, Chipepo Kankasa, Winslow Klaskala, Brad Brayfield, James Campbell, Quijiang Du, Ganapati Bhat, Francis Kasolo, Charles Mitchell, Charles Wood

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.

Original language	English (US)
Pages (from-to)	749-752
Number of pages	4
Journal	International Journal of Cancer
Volume	94
Issue number	5
DOIs	https://doi.org/10.1002/ijc.1529
State	Published - Dec 1 2001

Keywords

HHV-8
KSHV
Vertical transmission

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.1529

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title = "Vertical transmission of Kaposi's sarcoma-associated herpesvirus",

abstract = "Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.",

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T1 - Vertical transmission of Kaposi's sarcoma-associated herpesvirus

AU - Mantina, Hamakwa

AU - Kankasa, Chipepo

AU - Klaskala, Winslow

AU - Brayfield, Brad

AU - Campbell, James

AU - Du, Quijiang

AU - Bhat, Ganapati

AU - Kasolo, Francis

AU - Mitchell, Charles

AU - Wood, Charles

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.

AB - Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.

KW - HHV-8

KW - KSHV

KW - Vertical transmission

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JF - International Journal of Cancer

IS - 5

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Vertical transmission of Kaposi's sarcoma-associated herpesvirus

Abstract

Keywords

ASJC Scopus subject areas

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