Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice

Sherri M. Jones, Lawrence C. Erway, Rebecca A. Bergstrom, John C. Schimenti, Timothy A. Jones

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Vestibular evoked potentials (VsEPs) were measured in normal mice and in mice homozygous for the head tilt mutation (het/het, abbr. het). The het mice lack otoconia, the inertial mass critical for natural stimulation of inner ear gravity receptors. Our findings demonstrate that vestibular neural responses to pulsed linear acceleration are absent in het mice. The results: (1) confirm that adequate sensory stimuli fail to activate gravity receptors in the het model; and (2) serve as definitive evidence that far-field vestibular responses to pulsed linear acceleration depend critically on otolith end organs. The C57BL/6JEi-het mouse may be an excellent model of gravity receptor sensory deprivation. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalHearing Research
Volume135
Issue number1-2
DOIs
StatePublished - Sep 1999

Keywords

  • Gravity receptor
  • Mammal
  • Saccule
  • Utricle
  • Vestibular evoked potential

ASJC Scopus subject areas

  • Sensory Systems

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