Viral transformation for production of personalized type I interferons

Dongsheng Xu; Luwen Zhang

doi:10.1002/biot.201000038

Viral transformation for production of personalized type I interferons

Dongsheng Xu, Luwen Zhang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Type I interferons (IFN) are cytokines with many functions and have been widely used to treat many human diseases such as hepatitis C virus infection. Using the viral transformation and priming properties of Epstein-Barr virus, we have developed a system that can produce high levels of "personalized" IFNs, which are produced from the cells of the patient to whom the IFNs are to be administrated. We demonstrate the feasibility of the system. This seems to be the first report for the establishment of a personalized IFN-production system. The personalized IFNs could have a longer circulation time, fewer side effects but higher efficacy. We anticipate that the system can provide an improved form of IFN for medical uses.

Original language	English (US)
Pages (from-to)	578-581
Number of pages	4
Journal	Biotechnology Journal
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/biot.201000038
State	Published - Jun 2010

Keywords

Cytokine
Interferon
Personalized medicine
Red biotechnology
Type I IFNs

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Molecular Medicine

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10.1002/biot.201000038

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AB - Type I interferons (IFN) are cytokines with many functions and have been widely used to treat many human diseases such as hepatitis C virus infection. Using the viral transformation and priming properties of Epstein-Barr virus, we have developed a system that can produce high levels of "personalized" IFNs, which are produced from the cells of the patient to whom the IFNs are to be administrated. We demonstrate the feasibility of the system. This seems to be the first report for the establishment of a personalized IFN-production system. The personalized IFNs could have a longer circulation time, fewer side effects but higher efficacy. We anticipate that the system can provide an improved form of IFN for medical uses.

KW - Cytokine

KW - Interferon

KW - Personalized medicine

KW - Red biotechnology

KW - Type I IFNs

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Viral transformation for production of personalized type I interferons

Abstract

Keywords

ASJC Scopus subject areas

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