Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Guey Chuen Perng, Clinton Jones, Janice Ciacci-Zanella, Melissa Stone, Gail Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

Research output: Contribution to journalArticlepeer-review

341 Scopus citations

Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

Original languageEnglish (US)
Pages (from-to)1500-1503
Number of pages4
JournalScience
Volume287
Issue number5457
DOIs
StatePublished - Feb 25 2000

ASJC Scopus subject areas

  • General

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