Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

David E. Anderson; Sarah A. Holstein; Sachin Kedar

doi:10.1080/01658107.2019.1702703

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

David E. Anderson, Sarah A. Holstein, Sachin Kedar

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.

Original language	English (US)
Pages (from-to)	139-147
Number of pages	9
Journal	Neuro-Ophthalmology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1080/01658107.2019.1702703
State	Published - May 3 2020

Keywords

Cancer
chemotherapy
electroretinography
neurotoxicity
optical coherence tomography
retina

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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10.1080/01658107.2019.1702703

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title = "Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research",

abstract = "Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.",

keywords = "Cancer, chemotherapy, electroretinography, neurotoxicity, optical coherence tomography, retina",

author = "Anderson, {David E.} and Holstein, {Sarah A.} and Sachin Kedar",

note = "Funding Information: The authors would like to thank Deepta Ghate, M.D., Matthew Van Hook, Ph.D., and Wallace Thoreson, Ph.D. in the Department of Ophthalmology and Visual Sciences at the University of Nebraska Medical Center for valuable discussions related to this work. Funding for this research was provided by the Department of Ophthalmology and Visual Sciences at the University of Nebraska Medical Center. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",

year = "2020",

month = may,

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doi = "10.1080/01658107.2019.1702703",

language = "English (US)",

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T2 - A Review and Directions for Future Research

AU - Anderson, David E.

AU - Holstein, Sarah A.

AU - Kedar, Sachin

N1 - Funding Information: The authors would like to thank Deepta Ghate, M.D., Matthew Van Hook, Ph.D., and Wallace Thoreson, Ph.D. in the Department of Ophthalmology and Visual Sciences at the University of Nebraska Medical Center for valuable discussions related to this work. Funding for this research was provided by the Department of Ophthalmology and Visual Sciences at the University of Nebraska Medical Center. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2019, © 2019 Taylor & Francis Group, LLC.

PY - 2020/5/3

Y1 - 2020/5/3

N2 - Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.

AB - Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.

KW - Cancer

KW - chemotherapy

KW - electroretinography

KW - neurotoxicity

KW - optical coherence tomography

KW - retina

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Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

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Keywords

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