Visualization of thermally activated nanocarriers using in situ atomic force microscopy

Mingdong Dong, Kenneth A. Howard, David Oupicky, Harender Bisht, Jørgen Kjems, Flemming Besenbacher

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

Original languageEnglish (US)
Article number185501
JournalNanotechnology
Volume18
Issue number18
DOIs
StatePublished - May 9 2007
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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