Abstract
Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.
Original language | English (US) |
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Article number | 185501 |
Journal | Nanotechnology |
Volume | 18 |
Issue number | 18 |
DOIs | |
State | Published - May 9 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
- Electrical and Electronic Engineering