Visualization of thermally activated nanocarriers using in situ atomic force microscopy

Mingdong Dong; Kenneth A. Howard; David Oupicky; Harender Bisht; Jørgen Kjems; Flemming Besenbacher

doi:10.1088/0957-4484/18/18/185501

Visualization of thermally activated nanocarriers using in situ atomic force microscopy

Mingdong Dong, Kenneth A. Howard, David Oupicky, Harender Bisht, Jørgen Kjems, Flemming Besenbacher

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

Original language	English (US)
Article number	185501
Journal	Nanotechnology
Volume	18
Issue number	18
DOIs	https://doi.org/10.1088/0957-4484/18/18/185501
State	Published - May 9 2007
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

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AU - Howard, Kenneth A.

AU - Oupicky, David

AU - Bisht, Harender

AU - Kjems, Jørgen

AU - Besenbacher, Flemming

PY - 2007/5/9

Y1 - 2007/5/9

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AB - Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

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Visualization of thermally activated nanocarriers using in situ atomic force microscopy

Abstract

ASJC Scopus subject areas

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