Vitamin D and the thyroid

Shannon Wakeley, Whitney Goldner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Vitamin D deficiency has been implicated in the pathogenesis of several disease processes ranging from autoimmune disease to malignancy. Knowledge in the area of vitamin D deficiency has grown exponentially over recent years, and relationships between vitamin D and many disease conditions, including benign and malignant thyroid disease, have been discovered. Thyroid tissue expresses vitamin D receptors and in vitro studies have shown that 1,25(OH)2D (calcitriol) decreases proliferation and increases markers of differentiation in thyroid cancer cells. Vitamin D deficiency has also been found to have direct effects on thyroid function, playing a role in autoimmune hypo-and hyperthyroidism. This chapter will review the role of vitamin D in the thyroid by specifically looking at the function of vitamin D at the cellular level and its effects in both benign and malignant thyroid disease.

Original languageEnglish (US)
Title of host publicationVitamin D
Subtitle of host publicationBiochemistry, Nutrition and Roles
PublisherNova Science Publishers, Inc.
Pages129-146
Number of pages18
ISBN (Print)9781616682736
StatePublished - 2011

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Vitamin D and the thyroid'. Together they form a unique fingerprint.

  • Cite this

    Wakeley, S., & Goldner, W. (2011). Vitamin D and the thyroid. In Vitamin D: Biochemistry, Nutrition and Roles (pp. 129-146). Nova Science Publishers, Inc..