Vitamin D, infections and immune-mediated diseases

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Vitamin D has been an exciting field of research in recent years, with more than 1400 publications published on the subject in 2008. The lay press has published articles, the internet is full of information and pharmacies have prominent displays of vitamin D supplements. Historically, vitamin D has been thought only to have an effect on calcium metabolism and bone. Vitamin D deficiency was thought only to cause rickets or osteomalacia. Recent work has found that vitamin D affects many other cells and tissues. Basic science, epidemiological, case-control and cohort studies have been conducted that show an effect of vitamin D on infections and autoimmune diseases such as multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and Type 1 diabetes. Further research is needed in each of these areas to elucidate the mechanism vitamin D uses to affect the immune system and to develop prevention and/or treatment guidelines.

Original languageEnglish (US)
Pages (from-to)89-103
Number of pages15
JournalInternational Journal of Clinical Rheumatology
Volume4
Issue number1
DOIs
StatePublished - 2009

Keywords

  • 1,25-Dihydroxyvitamin D
  • 25-Hydroxyvitamin D
  • Autoimmune
  • Immunity
  • Infection
  • Vitamin D

ASJC Scopus subject areas

  • Rheumatology

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