Volume and shape in feature space on adaptive FCM in MRI segmentation

Renjie He, Balasrinivasa Rao Sajja, Sushmita Datta, Ponnada A. Narayana

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Intensity non-uniformity (bias field) correction, contextual constraints over spatial intensity distribution and non-spherical cluster's shape in the feature space are incorporated into the fuzzy c-means (FCM) for segmentation of three-dimensional multi-spectral MR images. The bias field is modeled by a linear combination of smooth polynomial basis functions for fast computation in the clustering iterations. Regularization terms for the neighborhood continuity of either intensity or membership are added into the FCM cost functions. Since the feature space is not isotropic, distance measures, other than the Euclidean distance, are used to account for the shape and volumetric effects of clusters in the feature space. The performance of segmentation is improved by combining the adaptive FCM scheme with the criteria used in Gustafson-Kessel (G-K) and Gath-Geva (G-G) algorithms through the inclusion of the cluster scatter measure. The performance of this integrated approach is quantitatively evaluated on normal MR brain images using the similarity measures. The improvement in the quality of segmentation obtained with our method is also demonstrated by comparing our results with those produced by FSL (FMRIB Software Library), a software package that is commonly used for tissue classification.

Original languageEnglish (US)
Pages (from-to)1580-1593
Number of pages14
JournalAnnals of biomedical engineering
Issue number9
StatePublished - Sep 2008
Externally publishedYes


  • Adaptive FCM
  • Contextual constraints
  • Feature space
  • G-G algorithm
  • G-K algorithm
  • Inhomogeneity field
  • MRI
  • Multispectral segmentation
  • Shape
  • Volume

ASJC Scopus subject areas

  • Biomedical Engineering


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