TY - JOUR
T1 - Walking abnormalities are associated with COPD
T2 - An investigation of the NHANES III dataset
AU - Yentes, Jennifer M.
AU - Sayles, Harlan
AU - Meza, Jane
AU - Mannino, David M.
AU - Rennard, Stephen I.
AU - Stergiou, Nicholas
N1 - Funding Information:
This work was supported by the Nebraska NASA Space Grant & EPSCoR Fellowship, the University of Nebraska Medical Center , Center for Clinical and Translational Research Pilot Grant Program, and the Nebraska Research Initiative . The funding sources had no involvement in the design, collection, or interpretation of data or writing of the manuscript.
PY - 2011/1
Y1 - 2011/1
N2 - Research on the peripheral effects of COPD has focused on physiological and structural changes. However, different from muscular weakness or decreased physical activity, mechanical abnormalities of the muscular system, e.g. walking, have yet to be investigated. Our purpose was to utilize the National Health and Nutritional Examination Survey (NHANES) dataset to determine whether walking abnormalities are associated with COPD severity. To determine if walking abnormalities were independently associated with COPD severity, our analysis aimed to investigate the association of physical activity levels with COPD severity and with walking abnormalities. The NHANES III dataset that contains data for 31,000 persons that were collected from 1988 to 1994, was used to explore the association of COPD severity on gross walking abnormalities, i.e. limp, shuffle, etc. Logistic regression models were created using FEV 1/FVC ratio, age, gender, BMI, and smoking status as predictors of walking abnormalities and physical activity in persons aged 40 to 90 years old. Results demonstrated a significant correlation between the presence of walking abnormalities and severe COPD (odds ratio: 1.97; 95% CI: 1.1 to 3.5). This suggests that disease severity can contribute to mechanical outcomes of patients with COPD. In addition, decreased physical activity levels were significantly associated with all COPD severity levels with the exception of mild COPD. The association between altered gait and COPD status may be due to the presence of physical inactivity that is present in patients with COPD. Future research directions should include investigating more closely the mechanical outcomes of persons with COPD.
AB - Research on the peripheral effects of COPD has focused on physiological and structural changes. However, different from muscular weakness or decreased physical activity, mechanical abnormalities of the muscular system, e.g. walking, have yet to be investigated. Our purpose was to utilize the National Health and Nutritional Examination Survey (NHANES) dataset to determine whether walking abnormalities are associated with COPD severity. To determine if walking abnormalities were independently associated with COPD severity, our analysis aimed to investigate the association of physical activity levels with COPD severity and with walking abnormalities. The NHANES III dataset that contains data for 31,000 persons that were collected from 1988 to 1994, was used to explore the association of COPD severity on gross walking abnormalities, i.e. limp, shuffle, etc. Logistic regression models were created using FEV 1/FVC ratio, age, gender, BMI, and smoking status as predictors of walking abnormalities and physical activity in persons aged 40 to 90 years old. Results demonstrated a significant correlation between the presence of walking abnormalities and severe COPD (odds ratio: 1.97; 95% CI: 1.1 to 3.5). This suggests that disease severity can contribute to mechanical outcomes of patients with COPD. In addition, decreased physical activity levels were significantly associated with all COPD severity levels with the exception of mild COPD. The association between altered gait and COPD status may be due to the presence of physical inactivity that is present in patients with COPD. Future research directions should include investigating more closely the mechanical outcomes of persons with COPD.
KW - Gait
KW - Locomotion
KW - Lung disease
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=78649939218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649939218&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2010.06.007
DO - 10.1016/j.rmed.2010.06.007
M3 - Article
C2 - 20615681
AN - SCOPUS:78649939218
VL - 105
SP - 80
EP - 87
JO - British Journal of Tuberculosis and Diseases of the Chest
JF - British Journal of Tuberculosis and Diseases of the Chest
SN - 0954-6111
IS - 1
ER -