Water insoluble and soluble lipids for gene delivery

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

Among various synthetic gene carriers currently in use, liposomes composed of cationic lipids and co-lipids remain the most efficient transfection reagents. Physicochemical properties of lipid/plasmid complexes, such as cationic lipid structure, cationic lipid to co-lipid ratio, charge ratio, particle size and zeta potential have significant influence on gene expression and biodistribution. However, most cationic lipids are toxic and cationic liposomes/plasmid complexes do not disperse well inside the target tissues because of their large particle size. To overcome the problems associated with cationic lipids, we designed water soluble lipopolymers for gene delivery to various cells and tissues. This review provides a critical discussion on how the components of water insoluble and soluble lipids affect their transfection efficiency and biodistribution of lipid/plasmid complexes.

Original languageEnglish (US)
Pages (from-to)699-712
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume57
Issue number5
DOIs
StatePublished - Apr 5 2005

Keywords

  • Biodistribution
  • Cationic liposomes
  • Gene delivery
  • Water soluble lipopolymers

ASJC Scopus subject areas

  • Pharmaceutical Science

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