Water soluble lipopolymers for gene delivery

Ram I. Mahato, Sung Wan Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Plasmid-based gene delivery systems utilize synthetic gene carriers to condense and protect plasmid DNA (pDNA) from premature degradation during storage and transportation from the site of administration to the site of gene expression.1-3 Plasmid DNA is condensed into a highly organized structure through a complex self-assembly process. Commonly utilized synthetic gene carriers are cationic lipids, polymers, and peptides that condense pDNA by virtue of their electrostatic interactions with the anionic phosphate backbone of the nucleic acid chain. Cationic copolymers synthesized by grafting polyethylenimine (PEI) with nonionic polymers, such as poly(ethylene oxide) (PEO) or Pluronic 123 have also been used for gene delivery.4 However, noncondensing polymers, such as poloxamers and polyvinyl pyrrolidone (PVP), are also being investigated for gene delivery to muscle and tumor tissues5,6 and will be discussed in a Chapters 19 and 20.

Original languageEnglish (US)
Title of host publicationPolymeric Gene Delivery
Subtitle of host publicationPrinciples and Applications
PublisherCRC Press
Pages175-186
Number of pages12
ISBN (Electronic)9780203500477
ISBN (Print)9780849319341
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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