@article{a54542620c7749db817cae601797eb5f,
title = "Wearable Devices for Single-Cell Sensing and Transfection",
abstract = "Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields.",
keywords = "biosensors, drug delivery, gene transfection, single cell, wearable electronics",
author = "Lingqian Chang and Wang, {Yu Chieh} and Faheem Ershad and Ruiguo Yang and Cunjiang Yu and Yubo Fan",
note = "Funding Information: L.C. and Y.F. acknowledge funding from INSCA of Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University . L.C. acknowledges start-up funding from University of North Texas . R.Y. acknowledges funding from the Nebraska Center for Integrated Biomolecular Communication (NCIBC) (NIH National Institutes of General Medical Sciences P20GM113126 ), from the Nebraska Center for Nanomedicine ( P30GM127200 ) and from the NSF (Award # 1826135 ). Y.C.W. is supported by the UNTHSC Start-up Fund for Stem Cell Laboratory and Faculty Pilot Grant FY15 ( RI6182 ). C.Y. would like to acknowledge NIH Grant ( R21EB026175 ) and a Doctoral New Investigator Grant from the American Chemical Society Petroleum Research Fund ( 56840-DNI7 ). Funding Information: L.C. and Y.F. acknowledge funding from INSCA of Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University. L.C. acknowledges start-up funding from University of North Texas. R.Y. acknowledges funding from the Nebraska Center for Integrated Biomolecular Communication (NCIBC) (NIH National Institutes of General Medical Sciences P20GM113126), from the Nebraska Center for Nanomedicine (P30GM127200) and from the NSF (Award #1826135). Y.C.W. is supported by the UNTHSC Start-up Fund for Stem Cell Laboratory and Faculty Pilot Grant FY15 (RI6182). C.Y. would like to acknowledge NIH Grant (R21EB026175) and a Doctoral New Investigator Grant from the American Chemical Society Petroleum Research Fund (56840-DNI7). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = nov,
doi = "10.1016/j.tibtech.2019.04.001",
language = "English (US)",
volume = "37",
pages = "1175--1188",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Limited",
number = "11",
}