West Nile virus infection in reindeer (Rangifer tarandus)

Mitchell V. Palmer; William C. Stoffregen; Douglas G. Rogers; Amir N. Hamir; Juergen A. Richt; Douglas D. Pedersen; W. Ray Waters

doi:10.1177/104063870401600307

West Nile virus infection in reindeer (Rangifer tarandus)

Mitchell V. Palmer, William C. Stoffregen, Douglas G. Rogers, Amir N. Hamir, Juergen A. Richt, Douglas D. Pedersen, W. Ray Waters

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Journal of Veterinary Diagnostic Investigation
Volume	16
Issue number	3
DOIs	https://doi.org/10.1177/104063870401600307
State	Published - May 2004

ASJC Scopus subject areas

General Veterinary

Access to Document

10.1177/104063870401600307

Cite this

@article{c9dc2c1aabf141d7a7cbd97c2e88e0a2,

title = "West Nile virus infection in reindeer (Rangifer tarandus)",

abstract = "West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).",

author = "Palmer, {Mitchell V.} and Stoffregen, {William C.} and Rogers, {Douglas G.} and Hamir, {Amir N.} and Richt, {Juergen A.} and Pedersen, {Douglas D.} and Waters, {W. Ray}",

year = "2004",

month = may,

doi = "10.1177/104063870401600307",

language = "English (US)",

volume = "16",

pages = "219--222",

journal = "Journal of Veterinary Diagnostic Investigation",

issn = "1040-6387",

publisher = "SAGE Publications Inc.",

number = "3",

}

TY - JOUR

T1 - West Nile virus infection in reindeer (Rangifer tarandus)

AU - Palmer, Mitchell V.

AU - Stoffregen, William C.

AU - Rogers, Douglas G.

AU - Hamir, Amir N.

AU - Richt, Juergen A.

AU - Pedersen, Douglas D.

AU - Waters, W. Ray

PY - 2004/5

Y1 - 2004/5

N2 - West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).

AB - West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).

UR - http://www.scopus.com/inward/record.url?scp=2442488736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442488736&partnerID=8YFLogxK

U2 - 10.1177/104063870401600307

DO - 10.1177/104063870401600307

M3 - Article

C2 - 15152836

AN - SCOPUS:2442488736

SN - 1040-6387

VL - 16

SP - 219

EP - 222

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

IS - 3

ER -

West Nile virus infection in reindeer (Rangifer tarandus)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this