TY - JOUR
T1 - What a fish can learn from a mouse
T2 - Principles and strategies for modeling human cancer in mice
AU - Bailey, Jennifer M.
AU - Creamer, Bradley A.
AU - Hollingsworth, Michael A.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - This review highlights the current techniques used to generate transgenic mouse models of cancer, with an emphasis on recent advances in the use of ubiquitous promoters, models that use Cre-loxP and Flip-FRT recombinase technology, inducible systems, RNAi to target genes, and transposon mutagenesis. A concluding section discusses new imaging systems that visualize tumor progression and the microenvironment in vivo. In this review, these techniques and strategies used in mouse models of cancer are highlighted, as they are pertinent and relevant to the development of zebrafish models of cancer.
AB - This review highlights the current techniques used to generate transgenic mouse models of cancer, with an emphasis on recent advances in the use of ubiquitous promoters, models that use Cre-loxP and Flip-FRT recombinase technology, inducible systems, RNAi to target genes, and transposon mutagenesis. A concluding section discusses new imaging systems that visualize tumor progression and the microenvironment in vivo. In this review, these techniques and strategies used in mouse models of cancer are highlighted, as they are pertinent and relevant to the development of zebrafish models of cancer.
UR - http://www.scopus.com/inward/record.url?scp=74049105523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049105523&partnerID=8YFLogxK
U2 - 10.1089/zeb.2009.0626
DO - 10.1089/zeb.2009.0626
M3 - Article
C2 - 20047466
AN - SCOPUS:74049105523
SN - 1545-8547
VL - 6
SP - 329
EP - 337
JO - Zebrafish
JF - Zebrafish
IS - 4
ER -