What's Nu(SAP) in mitosis and cancer?

Jyoti Iyer, Saili Moghe, Manabu Furukawa, Ming Ying Tsai

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Unperturbed mitosis is a prerequisite for the generation of two genetically identical daughter cells. Nucleolar-spindle associated protein (NuSAP) is an important mitotic regulator. The activity of NuSAP is essential for a variety of cellular events that occur during mitosis starting from spindle assembly to cytokinesis. In addition to playing crucial roles during mitosis, NuSAP has been in the spotlight recently due to different studies exhibiting its importance in embryogenesis and cancer. In this review, we have extensively mined the current literature and made connections between different studies involving NuSAP. Importantly, we have assembled data pertaining to NuSAP from several proteomic studies and analyzed it thoroughly. Our review focuses on the role of NuSAP in mitosis and cancer, and brings to light several unanswered questions regarding the regulation of NuSAP in mitosis and its role in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)991-998
Number of pages8
JournalCellular Signalling
Volume23
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Aurora B
  • Cell division cycle 2
  • Importin
  • Microtubule
  • Phosphorylation
  • Polo-like kinase-1

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'What's Nu(SAP) in mitosis and cancer?'. Together they form a unique fingerprint.

  • Cite this

    Iyer, J., Moghe, S., Furukawa, M., & Tsai, M. Y. (2011). What's Nu(SAP) in mitosis and cancer? Cellular Signalling, 23(6), 991-998. https://doi.org/10.1016/j.cellsig.2010.11.006