What's Nu(SAP) in mitosis and cancer?

Jyoti Iyer, Saili Moghe, Manabu Furukawa, Ming Ying Tsai

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Unperturbed mitosis is a prerequisite for the generation of two genetically identical daughter cells. Nucleolar-spindle associated protein (NuSAP) is an important mitotic regulator. The activity of NuSAP is essential for a variety of cellular events that occur during mitosis starting from spindle assembly to cytokinesis. In addition to playing crucial roles during mitosis, NuSAP has been in the spotlight recently due to different studies exhibiting its importance in embryogenesis and cancer. In this review, we have extensively mined the current literature and made connections between different studies involving NuSAP. Importantly, we have assembled data pertaining to NuSAP from several proteomic studies and analyzed it thoroughly. Our review focuses on the role of NuSAP in mitosis and cancer, and brings to light several unanswered questions regarding the regulation of NuSAP in mitosis and its role in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)991-998
Number of pages8
JournalCellular Signalling
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • Aurora B
  • Cell division cycle 2
  • Importin
  • Microtubule
  • Phosphorylation
  • Polo-like kinase-1

ASJC Scopus subject areas

  • Cell Biology


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