TY - JOUR
T1 - White matter differences between multiple system atrophy (parkinsonian type) and parkinson's disease
T2 - A diffusion tensor image study
AU - Ji, L.
AU - Wang, Y.
AU - Zhu, D.
AU - Liu, W.
AU - Shi, J.
N1 - Funding Information:
This work was supported by the Medical Science and Technology Development Foundation , Nanjing Department of Health (Nos. ZKX08035 and YKK11031 ) and Nanjing Bureau of Science and Technology (No. 201104009 ).
Publisher Copyright:
© 2015 IBRO.
PY - 2015
Y1 - 2015
N2 - The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for the first time to investigate three groups (15 MSA-P, 20 PD patients and 20 controls) with diffusion tensor imaging data. By TBSS, we performed pairwise comparisons of fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD) and axial diffusivity maps. The clusters with significant differences betweenMSA-P and PD were used as ROIs for further analyses. FA/RD values in bilateral corticospinal tract (CST) and left anterior thalamic radiation (ATR) in MSA-P were significantly different from PD or controls, and significantly correlated with clinical data. These findings indicated that the abnormalities of left ATR and bilateral CST were specific forMSA-P relative to PD or controls, and seemed to be promising for differential diagnosis. Furthermore, it may be useful for severity assessment of MSA-P.
AB - The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for the first time to investigate three groups (15 MSA-P, 20 PD patients and 20 controls) with diffusion tensor imaging data. By TBSS, we performed pairwise comparisons of fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD) and axial diffusivity maps. The clusters with significant differences betweenMSA-P and PD were used as ROIs for further analyses. FA/RD values in bilateral corticospinal tract (CST) and left anterior thalamic radiation (ATR) in MSA-P were significantly different from PD or controls, and significantly correlated with clinical data. These findings indicated that the abnormalities of left ATR and bilateral CST were specific forMSA-P relative to PD or controls, and seemed to be promising for differential diagnosis. Furthermore, it may be useful for severity assessment of MSA-P.
KW - Diffusion tensor imaging
KW - Multiple system atrophy
KW - Parkinson's disease
KW - Region of interest
KW - Tract-based spatial statistic
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U2 - 10.1016/j.neuroscience.2015.07.060
DO - 10.1016/j.neuroscience.2015.07.060
M3 - Article
C2 - 26215920
AN - SCOPUS:84951947136
VL - 305
SP - 109
EP - 116
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -