Whole-brain functional connectivity increases with extended duration of focal epileptiform activity

Deepak Madhavan, Elizabeth Heinrichs-Graham, Tony W. Wilson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


•We evaluated the relationship between epilepsy chronicity and whole-brain connectivity using MEG.•Whole-brain resting state MEG was analyzed using areas of interictal epileptiform discharges as seed regions.•We found a positive correlation between duration of epilepsy and functional connectivity in the beta band. The analysis of interictal epileptiform discharges (IEDs) using magnetoencephalography (MEG) is utilized for the localization of seizure onset zones in the presurgical planning of epilepsy patients. Additionally, resting-state functional connectivity analyses using the IED area may provide novel insight into the underlying brain networks. In this study, we evaluate whether chronicity of seizures is related to whole-brain functional connectivity metrics using the area of IED generation (derived from MEG) as the seed region. We found a positive correlation between the duration of seizures and beta-band functional connectivity between the epileptogenic zone and other brain areas. This suggests the presence of inhibitory GABAergic modulation of distal brain regions in response to chronic epileptiform activity.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalNeuroscience Letters
StatePublished - May 10 2013


  • Epilepsy
  • MEG
  • Magnetoencephalography
  • Phase coherence

ASJC Scopus subject areas

  • General Neuroscience


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