Why is the number of DNA bases 4?

Bo Deng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In this paper we construct a mathematical model for DNA replication based on Shannon's mathematical theory for communication. We treat DNA replication as a communication channel. We show that the mean replication rate is maximal with four nucleotide bases under the primary assumption that the pairing time of the G-C bases is between 1.65 and 3 times the pairing time of the A-T bases.

Original languageEnglish (US)
Pages (from-to)727-733
Number of pages7
JournalBulletin of Mathematical Biology
Issue number3
StatePublished - Apr 2006


  • Base pairing time
  • Communication channel
  • DNA replication
  • Data rate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics


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