Workshop report:Modeling the molecularmechanism of bacterial spore germination and elucidating reasons for germination heterogeneity

Karl J. Indest, Wallace G. Buchholz, Jim R. Faeder, Peter Setlow

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germinationwere presented and evaluated. As a result of these interactions, future research directionswere defined, the outcome of which should result in a robustmodel to help define themolecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores.

Original languageEnglish (US)
Pages (from-to)R73-R78
JournalJournal of food science
Volume74
Issue number6
DOIs
StatePublished - Aug 1 2009

Keywords

  • Bacterial spores
  • Microbial survival
  • Modeling

ASJC Scopus subject areas

  • Food Science

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