Yeast DNA polymerase ζ: Beyond translesion DNA synthesis

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1 Scopus citations

Abstract

DNA polymerase ζ (Pol ζ) is one of the key players in translesion DNA synthesis in eukaryotic cells. In both mammals and lower eukaryotes, Pol ζ is responsible for the generation of the majority of mutations induced by DNA-damaging agents. The mechanisms that regulate the participation of Pol ζ in DNA replication and its contribution to mutagenesis are currently a subject of active investigation. The author's group has found that the function of Pol ζ is not limited to lesion bypass. They have shown that Pol ζ can participate in DNA replication and cause increased mutagenesis in response to a variety of defects in the normal replication machinery. Currently, their research focuses on the mechanisms that license the access of Pol ζ to the primer terminus during DNA replication in the absence of exogenous DNA damage. The researchers have found that proliferating cell nuclear antigen (PCNA), a processivity factor of many nuclear DNA polymerases, plays at least three important and apparently separate roles in regulating Pol ζ-dependent mutagenesis. Initial evidence suggests that the pathways that lead to the recruitment of Pol ζ to the primer terminus, including the role of PCNA, are different in response to DNA damage and intrinsic replisome defects.

Original languageEnglish (US)
Pages (from-to)100-110
Number of pages11
JournalChemtracts
Volume19
Issue number3
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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