You can't handle the truth! Comparing serum phosphatidylethanol to self-reported alcohol intake in chronic liver disease patients

Kyle Scholten, Patrick Twohig, Kaeli Samson, Kevin Brittan, Alexandra Fiedler, Josh Warner, Tomoki Sempokuya, Anna Willet, Thoetchai(Bee) Peeraphatdit, Marco Olivera

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Serum phosphatidylethanol (PEth) testing has emerged as a promising biomarker for assessing recent alcohol consumption, surpassing the limitations of self-reported data. Limited clinical data exists comparing PEth levels and patients' reported alcohol intake. Aims: Compare PEth testing results with self-reported alcohol intake and assesses variables associated with underreporting. Methods: Single-center retrospective cohort of patients with a diagnosis of chronic liver disease and serum PEth. A patient's first positive PEth (>/=10 ng/mL) and self-reported alcohol consumption was used. PEth results were categorized as mild (10–20), moderate (20–200), or heavy (>200). Severity measures between self-report and PEth were assessed using Bhapkar's test and Bonferroni-adjusted McNemar's tests. Demographic data was analyzed using Chi-Square tests. Results: 279 patients were included. 94 (33.7%) patients had consistency with self-report, and 185 patients had inconsistencies in their report (66.3%, p < 0.001). Of 279 patients, 161 (57.7%) underreported their alcohol consumption, and 55 (19.7%) heavy PEth patients underreported alcohol consumption as light. 58% of alcohol-related and 56.4% of non-alcohol-related cirrhotic patients underreported their alcohol use. Conclusion: In our cohort, only one third of self-reported alcohol consumption was consistent with the PEth level. Notably, 57.7% underreported alcohol intake. Our study reinforces the clinical importance of PEth testing as an objective clinical measure.

Original languageEnglish (US)
JournalDigestive and Liver Disease
DOIs
StateAccepted/In press - 2024

Keywords

  • Alcohol use disorder
  • Chronic liver disease
  • Liver transplantation
  • Phosphatidylethanol

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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