Zinc signals in inflammation

Sannette C. Hall, Daren L. Knoell

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Zinc is an essential micronutrient for cell growth, differentiation, and survival and when deficient, is associated with increased susceptibility to infections and inflammatory disorders. Zinc homeostasis is critical for proper immune cell function and is therefore tightly regulated by zinc transporters. Recent evidence has highlighted zinc as an intracellular signaling molecule capable of modulating immune cell signaling. Slight changes in intracellular zinc, either by zinc deficiency or by excess zinc, can alter cellular signaling and immune cell function often resulting in increased inflammation. In this chapter, we discuss zinc signals in inflammation with a focus on zinc dependent modulation of select signaling pathways and the effects on immune cell function in response to potentially damaging challenges.

Original languageEnglish (US)
Title of host publicationZinc Signaling
PublisherSpringer Singapore
Pages279-304
Number of pages26
ISBN (Electronic)9789811505577
ISBN (Print)9789811505560
DOIs
StatePublished - Jan 1 2020

Keywords

  • Host defense
  • Inflammation
  • Innate and adaptive immunity
  • Zinc
  • Zinc deficiency
  • Zinc signal

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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